In a state whose demographics favored Bernie Sanders in every way imaginable, certainly more than most other states, a state that was, along with New Hampshire, a must win state for Sanders, Hillary Clinton has pulled out the victory.
Sanders and his campaign will no doubt try to claim they exceeded expectations and were the underdog and all of that, but there is no reasonable argument they can make that they can pull out a win over Clinton or in the general election if they could not win in a state tailor made for him.
I listened to some pundits try and claim that because the result was close the race will go on. They're wrong. With Clinton beating Sanders in a state he should have won and needed to win, the race is over.
Sanders will probably win New Hampshire, and will likely win Vermont when that state comes around, but Hillary will run the table beyond that.